Intestinal-specific TNFα overexpression induces Crohn's-like ileitis in mice.

Using our validated histological scoring system, we were able to detect significantly more villous distortion and total inflammation in TNF i∆ARE/i∆ARE → SCID mice compared to wt → SCID mice, and a strong trend towards more chronic inflammation as well (villous distortion index: 4.00 ± 0.00 vs. 2.00 ± 0.00, P<0.001; chronic inflammatory index: 4.5 ± 1.05 vs. 0.75 ± 0.75, P=0.06; total inflammatory score: 9.25 ± 1.19 vs. 3.25 ± 1.25, P<0.05).

also in 5,725 other papers