Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS.

In conclusion animal 4890 showed an initial acute infection-like condition after therapy suspension that was followed by improved control of viral load and an increasing trend toward normalization of the immunological parameters.

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The combined auranofin/H-iART therapy induced a significant reduction in the percentages of naïve cells (T N ; Figure 1 A) and a parallel reduction in the T N absolute numbers, although the latter did not reach statistical significance (Figure 1 B).

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This increase was paralleled by a decreasing trend in the T CM proportions and by a significant restriction of the T EM percentages (Figure 1 C).

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