Progressive alterations in microstructural organization and biomechanical response in the ApoE mouse model of aneurysm.

An increase nearing significance also occurred in fiber dispersion for the 14 d AngII infused wild-type mice, but was absent in the 28 d AngII infused wild-type mice.

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This remodeling between 14 and 28 d in the aneurysmal model is also suggested by the change in axial stiffness that occurred between 14 and 28 d in the ApoE −/− AngII infused aneurysmal mice, as there was initially a decrease in axial stiffness that was approaching significance, yet at 28 d ApoE −/− AngII infused aneurysmal mice had axial stiffness values closer to those found in the control mice.

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