Risk of hyperkalemia in patients with moderate chronic kidney disease initiating angiotensin converting enzyme inhibitors or angiotensin receptor blockers: a randomized study.

At 12 weeks we observed a trend towards higher plasma renin activity in both arms that did not reach statistical significance (1.13 ± 1.12 vs. 1.56 ± 1.77 and 1.30 ± 1.46 vs. 1.61 ± 1.83 ng/ml/h for olmesartan and enalapril respectively) and lower plasma aldosterone that was only significant (p < 0.05) for enalapril (27.6 ± 3.8 vs. 18.7 ± 2.9 ng/dl).

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