Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys.

BMC Neurosci · 2013 · PMC3751855 · PMID 23957861

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showed a trendno p-value reported

Additionally, all 5 genes appeared to exhibit a trend of altered expression at an early age, at least by 5 months; furthermore, NDUFA5 showed a trend of progressive dysregulation with age.

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an apparent trendno p-value reported

Notably, those same candidates also exhibited an apparent trend for altered expression in presymptomatic human HD patients, suggesting those transcripts may play a role in the earlier stages of HD pathogenesis (Additional file 5 ).

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