Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study.

Transl Psychiatry · 2013 · PMC3756291 · PMID 23942621

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

approaching significanceP <5 × 10 −7actually significant

18 This well-powered meta-analysis produced one genetic variant of genome-wide significance (cholinergic receptor, nicotinic, alpha 5, CHRNA5 SNP rs2036527, P <5 × 10 −8 ), several additional variants that were approaching significance ( P <5 × 10 −7 ) and many variants that fell short of statistical significance for the prediction of cigarettes smoked per day.

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