A SNP in the ADH1C gene that is always inherited together with (i.e., is in complete linkage disequilibrium) with one of the amino acid changes at this locus was associated with alcoholism in two GWASs candidate gene substudies on people of European descent, but the difference did not reach statistical significance for genome-wide analyses ( Kendler et al. 2011 ; Treutlein et al. 2009 ).
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