Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility.

However, due to the limited blood volumes that could be obtained during the acute stage in pediatric KD patients, the sample size of studies performed in primary B cells was small and we could not discern a clear trend of the association between risk variant of rs2736340 with the regulation of B cell receptor stimulation.

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