Gender-specific effects of genetic variants within Th1 and Th17 cell-mediated immune response genes on the risk of developing rheumatoid arthritis.

After correction for multiple testing using the SNP Spectral Decomposition Lite program (number of independent marker loci, 21; p = 0.05/21 = 0.002), only the Dectin-2 rs4264222 and Dectin-2 rs7134303 associations in women retained significance ( P = 3.00 E-04 and P = 9.00 E-04), whereas the associations with DC-SIGN rs4804803, MCP-1 rs1024611 and MCP-1 rs4586 showed borderline significance in the whole population ( P = 0.004, P = 0.006 and P = 0.009; Table 3 ).

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In addition, patients bearing the Dectin-2 rs7134303G allele showed a trend to have an increased risk for RA (OR = 1.35, 95%CI 1.00–1.83).

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We also found that women bearing the Dectin-2 rs7134303G tended to have an increased risk of the disease whereas those women carrying the MCP-1 rs4586C allele showed a borderline significant decreased risk for RA.

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