The impact of low-dose insulin on peripheral nerve insulin receptor signaling in streptozotocin-induced diabetic rats.

1b ) was decreased (mechanical hyperalgesia) by 10% (not significant; p > 0.05) and 16% (marginally significant; p = 0.05), respectively, compared with control rats.

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Insulin treatment approximately doubled non-fasting serum insulin levels from 0.17±0.03 ng/ml in the untreated diabetic group to 0.34±0.05 ng/ml in the treated group, but the difference between the two groups did not reach statistical significance ( Table 1 ).

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