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Dual targeting of the insulin-like growth factor and collateral pathways in cancer: combating drug resistance.

Cancers (Basel) · 2011 · PMC3759185 · PMID 24212944

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Although members of the IGF-1R family did not reach statistical significance for a priori inclusion within those subgroups, high IGF-1R, IGF-1, or IGF-2 levels portended sensitivity whereas elevated IGFBPs 3 and 6 were higher in resistant cell lines.

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