CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.

Cell Death Dis · 2013 · PMC3763465 · PMID 23990022

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did not reach statistical significanceno p-value reported

In case of CD40-stimulated cells, compound A decreased p65- and p52-binding activity, Bcl-XL and Bfl-1 expression, and also TNF α secretion somewhat, but these effects did not reach statistical significance ( Figures 2c–e ).

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