A double-blind, randomized, placebo-controlled study assessing the efficacy and tolerability of desvenlafaxine 10 and 50 mg/day in adult outpatients with major depressive disorder.

The primary efficacy end point of the adjusted mean change from baseline in the HAM-D 17 total score at the FOT evaluation did not reach statistical significance for patients in the desvenlafaxine 10 mg/day (-9.28) or desvenlafaxine 50 mg/day (-8.92) treatment groups vs placebo (-8.42; P =0.175 and P =0.421, respectively).

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