Integrative bioinformatics links HNF1B with clear cell carcinoma and tumor-associated thrombosis.

In total, we observed HNF1B expression in 66% of gynecologic and 56% of renal neoplasms with cytoplasmic clearing, compared to 5% and 16%, respectively, without cytoplasmic clearing, and compared to 1% of other neoplasms, all highly significant differences ( P <0.001; two-tailed Fisher exact tests) ( Fig. 1D , and Table S1 ).

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In renal tumors, HNF1B positivity showed a trend towards increased thromboembolic events ( P = 0.14, two-tailed Fisher’s exact test) ( Table 1 ).

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