Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis.

Front Psychiatry · 2013 · PMC3768116 · PMID 24032017

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0800

boldest claim

The sentences

highly significantp < 0.001actually significant

For the left DLPFC, the HC group showed a highly significant linear increase in activation with load ( p < 0.001), along with a non-significant trend toward a quadratic increase ( p = 0.09).

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a trend toward significancep = 0.06so close (0.05 < p ≤ 0.1)

Follow-up one-way ANOVAs at each Load indicated no significant main effects of Group, though a trend toward significance was observed at load 6 ( p = 0.06) with post hoc tests indicating a trend ( p = 0.08) toward deficient deactivation in the ESZ relative to the HC, similar to the pattern observed in the PCC.

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a statistical trendp = 0.08so close (0.05 < p ≤ 0.1)

The linear effect was explained by ESZ showing a significant increase in rDLPFC age-adjusted z -scores relative to CHR ( p = 0.05) and with a statistical trend toward an increase relative to HC ( p = 0.08).

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did not reach statistical significanceno p-value reported

Interestingly, while the lDLPFC appeared to be more activated than the right DLPFC in HC, especially at the highest load, group differences in the lDFLPC did not reach statistical significance in the overall ANOVA model.

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