Multi-modal neuroimaging in premanifest and early Huntington's disease: 18 month longitudinal data from the IMAGE-HD study.

Although the pre-HD group showed a trend in the same direction, the difference between pre-HD and symp-HD exhibited only a trend toward significance ( p = .058), and the difference between pre-HD and controls was not significant (see Figure 1 and Table 2 ; see Tables S1 and S2 for a full inventory of longitudinal within- and between-group regression coefficients and their statistical significance).

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The difference between symp-HD and pre-HD in the rate of putamen volume loss exhibited a trend toward significance (see Figure 1 ; see Tables S1 and S2 for a full inventory of longitudinal within- and between-group regression coefficients and their statistical significance).

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