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Guidelines for diagnosis and management of chronic obstructive pulmonary disease: Joint ICS/NCCP (I) recommendations.

Lung India · 2013 · PMC3775210 · PMID 24049265

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showed a trendno p-value reported
The beneficial effects of roflumilast on lung function were initially demonstrated in patients with moderate-to-severe COPD and severe COPD.[ 266 , 267 ] Both studies showed a trend towards lesser exacerbations with the use of roflumilast.

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