Mendelian randomization analysis of the effect of maternal homocysteine during pregnancy, as represented by maternal MTHFR C677T genotype, on birth weight.

J Epidemiol · 2013 · PMC3775531 · PMID 23856949

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closest p · 1.2× alpha

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boldest claim

The sentences

only marginally significantP = 0.06so close (0.05 < p ≤ 0.1)

Birth weight decreased by 120 to 130 grams as maternal homocysteine level increased (codominant model: β = −120.90, 95% CI −246.88 to 5.08; additive model: β = −130.28, 95% CI −266.68 to 6.13) after adjustment for potential confounding variables, although this association was only marginally significant ( P = 0.06).

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