The maximum C136U editing rate trended higher when the total number of monocyte-enriched PBMCs was over 21 million per well versus 20 million or less per well, though this difference did not reach statistical significance (10.9% ± 1.23%; n = 16 versus 8.54% ± 1.03%; n = 15; p = 0.1; Mann Whitney U test, one-sided).
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Hypoxia-inducible C-to-U coding RNA editing downregulates SDHB in monocytes.
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