Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments.

91 – 93 Reviews on second-generation antipsychotic or FGA depots (eg, bromperidol decanoate, haloperidol depot, risperidone depot, and fluphenazine decanoate) versus oral antipsychotic drugs and placebo indicated that patients with FGA depots had few relapses and fewer oral medications, even though the difference did not reach statistical significance. 94 – 96 Together with similar levels of adverse effects found in depot medications, it was also difficult to conclude that a particular depot was no better than any other depot or oral medication. 96 Despite showing similar clinical efficacy between oral and depot medications, depot injections can avoid frequent regular administration of and nonadherence to oral medication, rendering them more desirable for maintenance or compliance therapy.

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