Sepsis induced immunosuppression: Implications for secondary infections and complications.

re not significantly changed.[ 67 ] IFN-γ treatment between LPS administrations showed improvement in LPS-induced TNF-α responses, reduction in IL-10 levels and improved monocyte HLA-DR expression that were statistically significant; whereas similar patterns were seen with GM-CSF intervention, they did not reach statistical significance.[ 67 ] Conclusion Understanding of sepsis-induced immune dysfunction offers vast opportunities for improving the mortality and morbidity from prolonged ICU stays and secondary infections.

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