The IL23R A/Gln381 allele promotes IL-23 unresponsiveness in human memory T-helper 17 cells and impairs Th17 responses in psoriasis patients.

GG homozygous memory Th cells responded to IL-23 stimulation by secreting Th17 cytokines, and this secretion was attenuated in GA heterozygous, although it did not reach statistical significance (Δ IL-17A mean: GG 179 pg ml −1 , from −19 to 473 pg ml −1 , and GA 110 pg ml −1 , from −49 to 279 pg ml −1 ; Δ IL-17F median: GG 428 pg ml −1 , from −351 to 5,002 pg ml −1 , and GA 534 pg ml −1 , from −3269 to 4514 pg ml −1 ; Figure 2a and b ).

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