Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.

p110α inactivation reduces mural cell coverage of B16F1 tumor blood vessels Compared with B16F1 tumors in WT mice, tumor vessels in p110α D933A/WT mice showed a clear trend for decreased positivity for the mural cell marker α-SMA ( Fig. 2, A, B, and G ), with enhanced expression of the pericyte markers desmin ( Fig. 2, C, D, and H ) and NG2 ( Fig. 2, E, F, and I ).

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