MicroRNA-150 expression induces myeloid differentiation of human acute leukemia cells and normal hematopoietic progenitors.

Given the importance of miR-150 not only in myeloid differentiation, but also in megakaryocytic, lymphoid, and natural killer cell development, and most recently in adhesion of bone marrow progenitors, elucidating how miR-150 is regulated is also highly significant [ 9 , 28 - 30 , 56 ].

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In the adult AML patients a similar association between miR-150 expression and poor risk cytogenetic status was observed; however, these observations did not reach statistical significance in this smaller data set.

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