A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation.

Transl Psychiatry · 2013 · PMC3784764 · PMID 24002087

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.1100

boldest claim

The sentences

close to significanceP =0.053so close (0.05 < p ≤ 0.1)

In this analysis, the odds ratio (OR) remained high (OR=8.17) and the P- value remained close to significance ( P =0.053).

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did not reach statistical significanceP =0.11not close (p > 0.1)

Although we found a greater number of extremely rare missense variants in our ASD sample compared with our control sample (4% in ASD vs 1.7% in controls; Figure 1 ), this difference in the ‘rare missense variant burden' did not reach statistical significance (Fisher's exact test, P =0.11).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.