Control of the rescue and replication of Semliki Forest virus recombinants by the insertion of miRNA target sequences.

Consistently, the results of ICA in BHK-21 cells revealed that though all miR-cl2 targets reduced the infectivity of DNA/RNA layered SFV vectors the effect did not reach statistical significance even for pCMV-SFV4-2SG-Gluc-miR-cl2P (p = 0.081) ( Fig. 6B ). miR-cl2N target failed to significantly reduce infectious virus rescue also in HeLa cells ( Fig. 6C ).

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