miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.

We found mild repression of luciferase activity by individual miRNAs, which did not reach statistical significance, whereas the transfection with all three miRNAs resulted in approximately a 60% decrease in activity, suggesting that they act cooperatively ( P <0.05, n =3) ( Figure 2a ).

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