DNA methylation mediates persistent epileptiform activity in vitro and in vivo.

The difference in average DNA methylation of the 3 CpGs in this region was highly significant as well (p<0.001).

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The low seizure rats expressed on average 11.5% higher levels of mRNA than the high seizure rats but the difference between the high and low seizure groups did not reach statistical significance due to high variability in expression in the group and reduced numbers once the treated group was subdivided to low and high seizures.

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