MAL hypermethylation is a tissue-specific event that correlates with MAL mRNA expression in esophageal carcinoma.

Sci Rep · 2013 · PMC3789153 · PMID 24088706

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a strong trendno p-value reported

In a prospective cohort study of 309 Barrett's patients followed in the Seattle Barrett's Esophagus Project, a strong trend was observed, with a 5 cm difference in length associated with a 1.7-fold increase in cancer risk (95% CI, 0.8–3.8-fold), when patients with HGD at entrance were excluded 36 .

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