Alterations of tear mediators in patients with keratoconus after corneal crosslinking associate with corneal changes.

PLoS One · 2013 · PMC3790710 · PMID 24124547

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a decreasing trendno p-value reported

A decreasing trend towards the T H 1 cytokines (IFNγ) in KC, may suggest presence of complex imbalance in the cytokines leading to altered epithelial and stromal function in this disease [ 16 ].

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an increasing trendno p-value reported

observed decreased IL-13 level in tears of severe KC and an increasing trend in IL-17 [ 16 ].

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failed to reach statistical significanceno p-value reported

The changes in the concentration of all the mediators 38 days after CXL compared with the baseline failed to reach statistical significance, and the volume of the collected tears returned back to the pre-CXL levels.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.