Rab3a is critical for trapping alpha-MSH granules in the high Ca²⁺-affinity pool by preventing constitutive exocytosis.

The application of KCl triggered reduced Ca 2+ -dependent release of α-MSH from Rab3a KO slices (2.18±0.05 nM) compared to WT slices (2.41±0.04 nM), but this did not reach statistical significance ( Figure 6D ).

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