The untreated WT and SPARC KO controls all had a histological score of 0, while the DSS-treated SPARC KO animals had a lower histological inflammatory score ( Figure 4B ) than the WT mice but this did not reach statistical significance.
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Secreted protein acidic and rich in cysteine (SPARC) exacerbates colonic inflammatory symptoms in dextran sodium sulphate-induced murine colitis.
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