SMAD3 rs17228212 gene polymorphism is associated with reduced risk to cerebrovascular accidents and subclinical atherosclerosis in anti-CCP negative Spanish rheumatoid arthritis patients.

PLoS One · 2013 · PMC3804609 · PMID 24204921

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did not reach statistical significanceno p-value reported

Although results did not reach statistical significance, this increase of C allele frequency is in line with previous results that reported an increased risk of CAD associated to C allele in individuals without RA [ 6 ].

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