In hippocampus from cases of familial AD there was a slight (27%) increase in BIN1 compared to the age-matched controls but this did not reach statistical significance (mean ± SD; controls 1.00 ± 0.62 and familial AD samples 1.27 ± 0.67, p = 0.488) ( Figure 1C and D ).
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BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging.
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