Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats.

Although the reduction of cardiac ACE2 protein expression by E2 did not reach statistical significance in the Western blot analysis, perhaps due to the small sample size (n = 5) or antibody sensitivity, E2 treatment significantly reduced cardiac ACE2 mRNA levels and the intensity of LV tissue expression by immunohistochemistry staining.

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