Plasmodium falciparum mutant haplotype infection during pregnancy associated with reduced birthweight, Tanzania.

When using z -scores (adjusting for gestational age at delivery and sex of newborn) based on a Tanzanian reference chart from the same cohort ( 23 ), borderline significance toward lower z -scores in women with sextuple mutant haplotype infections was observed (p = 0.06).

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In our study, sextuple haplotype parasite infections were associated with reduced weight of the placenta, although this difference did not reach statistical significance.

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This could explain why the difference in z -scores between the sextuple and less mutated haplotypes was only borderline significant ( Table 2 ).

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