Dissociable effects of 5-HT2C receptor antagonism and genetic inactivation on perseverance and learned non-reward in an egocentric spatial reversal task.

Although the difference failed to reach significance, SB242084 treated animals made more incorrect responses in the learned non-reward test (F 1, 22 = 2.97, p = ns).

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The near-significant effects of genotype on trials ( Fig. 2C ) and incorrect responses ( Fig. 2D ) to criterion in the full reversal test could be accounted for by retarded egocentric discrimination learning (trials, F 1,30 = 0.64, p = .43; incorrect responses, F 1,30 = 0.57, p = .46).

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