Mentalizing and motivation neural function during social interactions in autism spectrum disorders.

Thus, while controls showed differentiation between Show and No-Show events in the Human Opponent runs as expected (this difference in the Computer Opponent runs showed significance on the right MTG: t = 2.62, p = 0.01 and only a trend toward significance on the left ( t = 2.04, p = 0.06)), ASD subjects showed no differentiation between the Human Show and No-Show conditions with a much weaker main effect of Opponent Type (due to a differentiation between the Computer Show and No-Show events; see Fig. 3 C and D). 3.2.3.

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While TD showed reward-related activation (gains > losses) in this region overall ( t = 4.86, p = 0.0002) and separately for both Human and Computer runs ( t = 4.37, p = 0.0005 and t = 3.94, p = 0.001, respectively), individuals with ASDs showed a trend for this effect in Computer runs only ( t = 1.62; p = 0.06); Fig. 4 C). 3.2.6.

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