borderline significantP = 0.057
In nondiabetic subjects, although a similar trend was observed, the interaction term was borderline significant ( P = 0.057).
In nondiabetic subjects, although a similar trend was observed, the interaction term was borderline significant ( P = 0.057).
Association between the TCF7L2 -rs7903146 polymorphism and type 2 diabetes, fasting glucose, and plasma lipid concentrations at baseline As expected, this polymorphism presented a highly significant association with type 2 diabetes ( Supplementary Table 2 ), TT individuals having greater risk compared with CC homozygotes (odds ratio 1.87 [95% CI 1.62–2.17]).
In the stratified analysis by type 2 diabetes, we observed higher HRs in subjects with type 2 diabetes, but the results did not reach statistical significance.