Hepatic insulin clearance is closely related to metabolic syndrome components.

Both indices of HIC showed a trend of an association with increased risk of metabolic syndrome (HIC C-peptide odds ratio 1.13 [95% CI 0.97–1.31], P = 0.12, and HIC ISR 1.38 [0.88–2.17], P = 0.16) and impaired glucose metabolism (HIC C-peptide 1.12 [0.92–1.36], P = 0.26, and HIC ISR 1.31 [0.74–2.33] P = 0.36), although point estimates reached no statistical significance.

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In our study, we identified highly significant correlations between OGTT-derived HIC indices and different components of metabolic syndrome, in agreement with previous results from other studies ( 4 , 6 , 13 ).

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