Because the extensive metabolizer group has been broadly defined as having “at least one” active allele, an analysis was performed to determine if a semi-quantitative dose effect could be observed amongst different allele combinations.( 13 , 15 ) After assigning a score of 1 for each fully active allele, 0.5 for alleles with decreased activity, and 0 for inactive alleles/deletions, a clear trend towards decreased metabolism with lower semi-quantitative dose was noted with regards to peak metoprolol concentration and AUC (see Table 3 ).
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A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics.
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