Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.

However, IGF-2 χ diet interaction revealed a borderline significance for increased Aβ1–40 levels in A+I+ female mice on TWD [ F (1,26) ∇ 4.0, P ∇ 0.06] ( Fig. 5A ).

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On the other hand, the effect of diet approached significance in male mice [ F (1,66) ∇ 3.6, P ∇ 0.06], as all mice on TWD, except the A+I+ mice, moved less than the mice on STD ( Fig. 3E and F).

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