Surface-layer protein A (SlpA) is a major contributor to host-cell adherence of Clostridium difficile.

PLoS One · 2013 · PMC3827033 · PMID 24265687

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As a group, ribotype 078 strains derived from human CDI cases showed a trend to adhere at higher levels to human intestinal epithelial monolayers, compared with those derived from porcine cases (lower adherence) and bovine cases (least adherence) ( p = 0.11; Figure 2 ).

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