Impaired antibody response to influenza vaccine in HIV-infected and uninfected aging women is associated with immune activation and inflammation.

PLoS One · 2013 · PMC3827419 · PMID 24236161

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did not reach statistical significanceno p-value reported

A trend of IL-21R upregulation in B cells was also observed, even though it did not reach statistical significance likely due to small sample size.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.