Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma.

The level of circulating Lin28B had a significant association with high BCLC stage (stage B to C diseases versus A1 to A4 diseases) (P=0.022) ( Figure S6A ) and had a borderline significance in associated with high AJCC stage (stage IIIC to IVA diseases versus I to IIIB diseases) (P=0.066) ( Figure S6B ).

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If further stratified by AJCC stage, circulating Lin28B significantly correlated with RFS in earlier stages (stage I and stage II) (P=0.003) ( Figure 3E ) although it did not reach statistical significance in patients with more advanced stages (P=0.419) ( Figure 3F ).

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