Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction.

Evaluation by qRT‐PCR ( Figure 3 A) revealed that hearts in the DZF Scr cohort exhibited an upregulation in ICAM‐1, VCAM‐1, and tissue factor mRNA compared with the sham control group, although these did not reach statistical significance at the 48‐hour time point measured.

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