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The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines.

Front Immunol · 2013 · PMC3834611 · PMID 24312098

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As shown in Figure 7 , the mature form but not the precursor of IL-33 was active but did not reach statistical significance until 1.3 nM concentration.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.