Furthermore, reaction time showed a trend for becoming slower with increasing MPEP dosage in both genotypes, with Fmr1 -KO mice responding overall significantly quicker to the correct aperture, reflective of quicker reaction times during earlier 5CSRTT learning phases (Figure 6D {2-way repeated measurements ANOVA [MPEP effect F (2, 54) = 2.26, p = 0.10], [Genotype effect p (1, 27) = 6.32, p = 0.01], [Interaction effect p (2, 54) = 0.17, p = 0.84]}).
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Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model.
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