Oncostatin M and TLR-4 ligand synergize to induce MCP-1, IL-6, and VEGF in human aortic adventitial fibroblasts and smooth muscle cells.

In contrast, LIF, IL-31, IL-11, and IL-6 showed a trend to suppress the LPS-induced MCP-1 ( Figure 1 ), but this was consistently observed with LIF and IL-11 (and not IL-31 or IL-6) and only at 10 ng/mL (but not other concentrations) of LPS ( Figure 2 ).

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