Resequencing three candidate genes for major depressive disorder in a Dutch cohort.

First of all, in the Sullivan GWAS, rs2522833 only became nominally significant after post-hoc analysis with a cohort that used a similar method of ascertainment.

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In the GAIN-MDD GWAS however, had rare variants been causal, there would not have been a marginally significant signal, unless if these rare variants would all have been recent and in the same haplotype.

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